Dyslexia: Sudden onset of 'Word Blindness'

In the journal Neurology, researchers report a novel technique that enables a patient with "word blindness" to read again.

Word blindness is a rare neurological condition. (The medical term is "alexia without agraphia.") Although a patient can write and understand the spoken word, the patient is unable to read.

Here's how the technique works: When shown a word, the patient looks at the first letter. Although she clearly sees it, she cannot recognize it.

So, beginning with the letter A, she traces each letter of the alphabet over the unknown letter until she gets a match.

For example, when shown the word Mother, she will trace the letters of the alphabet, one at a time, until she comes to M and finds a match. Three letters later, she guesses correctly that the word is Mother.

"To see this curious adaption in practice is to witness the very unique and focal nature" of the deficit, the authors write.

The authors describe how word blindness came on suddenly to a 40-year-old kindergarten teacher and reading specialist.

She couldn't make sense of her lesson plan, and her attendance sheet was as incomprehensible as hieroglyphs. She also couldn't tell time.

The condition was due to a stroke that probably was caused by an unusual type of blood vessel inflammation within the brain called primary central nervous system angiitis.

Once a passionate reader, she was determined to learn how to read again. But none of the techniques that she had taught her students – phonics, sight words, flash cards, writing exercises, etc. – worked.

So she taught herself a remarkable new technique that employed tactile skills that she still possessed.

The woman can have an emotional reaction to a word, even if she can't read it. Shown the word "dessert," she says "Oooh, I like that." But when shown "asparagus," she says, "Something's upsetting me about this word."

Shown two personal letters that came in the mail, she correctly determined which was sent by a friend of her mother's and which was sent by one of her own friends.

"When asked who these friends were, she could not say, but their names nevertheless provoked an emotional response that served as a powerful contextual clue," the authors write.

What she most misses is reading books to children. She teared up as she told the authors: "One day my mom was with the kids in the family, and they were all curled up next to each other, and they were reading. And I started to cry, because that was something I couldn't do."

More Information: 'Right Brain: A reading specialist with alexia without agraphia' A Teacher interrupted Jason Cuomo, MA, Murray Flaster, MD, PhD and José Biller, MD: doi: 10.1212/01.wnl.0000438218.39061.93

Recession onset spurs harsh parenting

The onset of the Great Recession and, more generally, deteriorating economic conditions lead mothers to engage in harsh parenting, such as hitting or shouting at children, a team of researchers has found. But the effect is only found in mothers who carry a gene variation that makes them more likely to react to their environment.

The study, conducted by scholars at New York University, Columbia University, Princeton University, and Pennsylvania State University's College of Medicine, appears in the journal Proceedings of the National Academy of Sciences (PNAS).

"It's commonly thought that economic hardship within families leads to stress, which, in turn, leads to deterioration of parenting quality," said Dohoon Lee, an assistant professor of sociology at NYU and lead author of the paper.

"But these findings show that an economic downturn in the larger community can adversely affect parenting—regardless of the conditions individual families face."

Dohoon Lee

The researchers found that harsh parenting increased as economic conditions worsened only for those with what has been called the "sensitive" allele, or variation, of the DRD2 Taq1A genotype, which controls the synthesis of dopamine, a behaviour-regulating chemical in the brain.

Deteriorating economic conditions had no effect on the level of harsh parenting of mothers without the 'sensitive allele'. Just more than half of the mothers in the study had the sensitive, or T, allele.

Likewise, the researchers found that mothers with the 'sensitive allele' had lower levels of harsh parenting when economic conditions were improving compared with those without the sensitive allele.

Irwin Garfinkel

"This finding provides further evidence in favor of the orchid-dandelion hypothesis that humans with sensitive genes, like orchids, wilt or die in poor environments, but flourish in rich environments, whereas dandelions survive in poor and rich environments," said Irwin Garfinkel, a co-author of the paper and the Mitchell I. Ginsberg Professor of Contemporary Urban Problems at the Columbia University School of Social Work (CUSSW).

The findings were based on data from the Fragile Families and Child Wellbeing Study (FFS), a population-based, birth cohort study conducted by researchers at Princeton and Columbia of nearly 5,000 children born in 20 large American cities between 1998 and 2000.

Mothers were interviewed shortly after giving birth and when the child was approximately 1, 3, 5, and 9 years old. Data on harsh parenting were collected when the child was 3, 5, and 9 years old. In Year 9, saliva DNA samples were collected from 2,600 mothers and children.

Harsh parenting was measured using 10 items from the commonly used Conflict Tactics Scale—five items measured psychological harsh parenting (e.g., shouting, threatening, etc.) and five gauged corporal punishment (e.g., spanking, slapping).

The researchers supplemented these data with measurements of economic conditions in each of the 20 cities where the FFS mothers lived.

Specifically, they examined city-level data on monthly unemployment rates, obtained from the Bureau of Labor Statistics' Local Area Unemployment Statistics, and the Consumer Sentiment Index, obtained from the Thomson Reuters/University of Michigan Surveys of Consumers.

In their analysis, they controlled for age, race/ethnicity, immigration status, educational attainment, poverty status, family structure, and child gender and child age (in months) at the time of interview.

The results showed that, contrary to common perceptions, harsh parenting was not positively associated with high levels of unemployment among those studied.

Rather, these behaviours were linked to increases in a city's unemployment rate and declines in national consumer sentiment, or confidence, in the economy.

The researchers concluded that it is the anticipation of adversity i.e the fear of losing one's job due to deteriorating economic conditions, that is a more important determinant of harsh parenting than poor economic conditions or even actual economic hardship a family faces.

Sara McLanahan

"People can adjust to difficult circumstances once they know what to expect, whereas fear or uncertainty about the future is more difficult to deal with," said Sara McLanahan, Princeton's William S. Tod Professor of Sociology and Public Affairs and a co-author of the paper.

In the past, researchers have focused on "bad" or "risky" genes and difficult environments without giving enough attention to how people with these genes may perform in high-quality environments, McLanahan said.

More information: www.pnas.org/cgi/doi/10.1073/pnas.1306440110