Childhood Bullying Has Long term Effects: Mood Disorders

Bullying by peers changes the structure surrounding a gene involved in regulating mood, making victims more vulnerable to mental health problems as they age.

This is the reported finding of a recent study by a researcher at the Centre for Studies on Human Stress (CSHS) at the Hôpital Louis-H. Lafontaine and professor at the Université de Montréal suggests that .

The study published in the journal Psychological Medicine seeks to better understand the mechanisms that explain how difficult experiences disrupt our response to stressful situations.

"Many people think that our genes are immutable; however this study suggests that environment, even the social environment, can affect their functioning. This is particularly the case for victimization experiences in childhood, which change not only our stress response but also the functioning of genes involved in mood regulation," says Isabelle Ouellet-Morin, lead author of the study.

A previous study by Ouellet-Morin, conducted at the Institute of Psychiatry in London (UK), showed that bullied children secrete less cortisol -- the stress hormone -- but had more problems with social interaction and aggressive behaviour.

The present study indicates that the reduction of cortisol, which occurs around the age of 12, is preceded two years earlier by a change in the structure surrounding a gene (SERT) that regulates or transports serotonin, and is a neurotransmitter involved in mood regulation and depression.

To achieve these results, 28 pairs of identical twins with a mean age of 10 years were analyzed separately according to their experiences of bullying by peers: one twin had been bullied at school while the other had not.

"Since they were identical twins living in the same conditions, changes in the chemical structure surrounding the gene cannot be explained by genetics or family environment. Our results suggest that victimization experiences are the source of these changes," says Ouellet-Morin.

According to the author, it would now be worthwhile to evaluate the possibility of reversing these psychological effects, in particular, through interventions at school and support for victims.

BiPolar Disorder: Cannabis increases neuro-cognitive performance

According to a study published online in the journal Psychiatry Research, individuals with bipolar disorder who used cannabis showed higher neuro-cognitive performance than patients who did not use cannabis.

The Researchers; The Zucker Hillside Hospital in Long Island, NY, in collaboration with a team at the Mount Sinai School of Medicine and the Albert Einstein College of Medicine in New York City.

They examined the difference in cognitive performance among 50 individuals with bipolar disorder who had a history of cannabis use, with 150 bipolar patients who had no history of cannabis use.

Both groups of patients were similar in age at bipolar onset. In addition, the groups did not differ in racial background, age, or highest education level achieved.

The team discovered that patients who used cannabis showed superior neuro-cognitive performance than those who did not. However, patients who used cannabis did not differ considerably on estimates of premorbid IQ.

The researchers explained: "Results from our analysis suggest that subjects with bipolar disorder and history of (cannabis use) demonstrate significantly better neurocognitive performance, particularly on measures of attention, processing speed, and working memory.

These findings are consistent with a previous study that demonstrated that bipolar subjects with history of cannabis use had superior verbal fluency performance as compared to bipolar patients without a history of cannabis use.

Similar results have also been found in schizophrenia in several studies."

They concluded, "The data could be interpreted to suggest that cannabis use may have a beneficial effect on cognitive functioning in patients with severe psychiatric disorders.

However, it is also possible that these findings may be due to the requirement for a certain level of cognitive function and related social skills in the acquisition of illicit drugs."

What is Bipolar Disorder?  
Bipolar disorder, more commonly known in the past as manic depression or manic depressive illness, is a mental disorder in which the patient has mood instability, often severe. In severe cases the illness can be very disabling, psychologically and socially.

An individual with bipolar disorder typically has unusual shifts in mood, energy, and the ability to function - these changes can last for weeks and sometimes months.

The fluctuations present in bipolar disorder are much more severe than the "ups-and-downs" we all go through. The changes are much steeper and last longer.

They can damage relationships, destroy job prospects, and undermine school performance. Some patients find their symptoms so unbearable that they attempt to commit suicide.