Their study is the first to directly compare brain anatomy of females with and without dyslexia.
Credit: © Lucian Milasan / Fotolia
Using MRI, neuroscientists at Georgetown University Medical Center found significant differences in brain anatomy when comparing men and women with dyslexia to their non-dyslexic control groups, suggesting that the disorder may have a different brain-based manifestation based on sex.
Their study, investigating dyslexia in both males and females, is the first to directly compare brain anatomy of females with and without dyslexia (in children and adults).
Their findings were published online in the journal Brain Structure and Function.
"It has been assumed that results of studies conducted in men are generalisable (sic) to both sexes, but our research suggests that researchers need to tackle dyslexia in each sex separately to address questions about its origin and potentially, treatment," Eden says.
Previous work outside of dyslexia demonstrates that male and female brains are different in general, adds the study's lead author, Tanya Evans, PhD.
"It is also known that sex hormones are related to brain anatomy and that female sex hormones such as estrogen can be protective after brain injury, suggesting another avenue that might lead to the sex-specific findings reported in this study."
The study of 118 participants compared the brain structure of people with dyslexia to those without and was conducted separately in men, women, boys and girls.
- In the males, less gray matter volume is found in dyslexics in areas of the brain used to process language, consistent with previous work.
- In the females, less gray matter volume is found in dyslexics in areas involved in sensory and motor processing.
The results have important implications for understanding the origin of dyslexia and the relationship between language and sensory processing, says Evans.
- Tanya M. Evans, D. Lynn Flowers, Eileen M. Napoliello, Guinevere F. Eden. Sex-specific gray matter volume differences in females with developmental dyslexia.Brain Structure and Function, 2013; DOI: 10.1007/s00429-013-0552-4